British actor, who played Kevan Lannister in the hit fantasy drama series, Ian Gelder was diagnosed with bile duct cancer last December and died just after 1 pm on Monday.
His death was announced by his husband, fellow actor Ben Daniels, who paid tribute to the "kindest, most generous-spirited and loving human being".
Daniels, 59, said Gelder was his "absolute rock" during their relationship of more than 30 years.
The star wrote on social media: "It is with huge huge sadness and a heavy heart broken into a million pieces that I'm leaving this post to announce the passing of my darling husband and life partner Ian Gelder."
Alongside his announcement on Instagram, Daniels shared a picture of the couple which he said was taken at Christmas after Gelder had left the hospital.
Gelder first played Kevan Lannister in the opening season of Game Of Thrones in 2011.
He was the younger brother of Lord Tywin Lannister and was one of his most loyal and trusted officers in the Lannister armies.
After a noticeable absence, Gelder reprised his character in later seasons, meeting his demise in the final episode of season six.